La Misión is situated in the historic district of Recoleta, a 15-minute drive from the International Airport. The rooftop pool provides panoramic views and WiFi is free in all rooms. Guestrooms at La Mision Hotel Boutique feature diverse artwork in the form of paintings, wood and stone sculptures, and indigenous basketwork dating back to the era of the Jesuit Missions. A large buffet breakfast, and a diverse international menu for lunch and diner are served in the on site restaurant, Paraquaria. The guest bedrooms at La Misión feature an elegant décor which combines modern and traditional styles with a Guarani feel, and come with air conditioning, an en suite bathroom and a plasma-screen cable TV. Some rooms feature balconies with far-reaching views across Asunción. The lobby bar Mi Terruño offers nice snacks, natural fruit juices and tropical drinks throughout the day. Guests at Hotel Boutique La Mision can also unwind in the garden, which boasts orchids and exotic plants.The rooftop terrace features sun loungers and the roof garden also becomes the venue for relaxing jazz recitals during the weekends. La Mision Hotel Boutique has solar panels to heat water. La Misión Boutique Hotel is just 3 km from the Mercado Cuatro. The hotel offers transfers to and from airport and additional tours of the city.

Couples particularly like the location — they rated it 9.8 for a two-person trip.